Made in USA · ≥99% HPLC
Bioregulator Peptide
Epithalon 10mg
EpitalonAEDG tetrapeptidetelomerase research
A synthetic pineal tetrapeptide (Ala-Glu-Asp-Gly) studied for telomerase activity and pineal circadian signaling, supplied as 10 mg sterile lyophilized powder for in-vitro research.
$59.95
47 in stock
For laboratory and research use only. Not for human consumption.
This product is not a drug, food or cosmetic. It is sold exclusively to qualified researchers and licensed laboratories.
47 in stock
Tested by Freedom Diagnostics TestingHPLC purity + LC-MS identityLot-matched COA on-site
Arrives in 3–5 days
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US-synthesizedMade & lab-released in the United States
Independent COAThird-party Certificate of Analysis per lot
HPLC + LC-MSPurity by HPLC, identity by mass spectrometry
Same-day dispatchOrders before 2 PM CT ship the same business day
What is Epithalon?
Epithalon is a small synthetic peptide made of four amino acids: alanine, glutamic acid, aspartic acid, and glycine (Ala-Glu-Asp-Gly). Researcher Vladimir Khavinson developed it at the St. Petersburg Institute of Bioregulation and Gerontology as a lab-made version of epithalamin, a natural substance from the pineal gland. With just four amino acids, it is one of the smallest peptides used in this area of research.
Laboratories use epithalon mostly in two areas: telomere biology, and the pineal gland and melatonin signaling. In cell studies, researchers measure its effect on telomerase — the enzyme that maintains the ends of chromosomes — and use it in replicative senescence assays. In animal models, they measure melatonin and circadian signaling, telomere and senescence markers, and oxidative-stress and DNA-stability markers. The material supplied here is research-grade for in vitro laboratory study only.
Every lot, independently verified
Independently third-party tested and matched to the lot ID printed on your vial. Values below are from the latest released lot.
99.12%
HPLC-UV Purity
Passed full QC panel
Independent third-party lab (Freedom Diagnostics Testing)
View COA (PDF)
Latest batch · tested 10 Jun 2026 · Freedom Diagnostics (USA)
Lot details
ProductEpithalon 10 mg
Lot612026EP
AppearanceWhite lyophilized powder
Accession #2606080818
Reported10 Jun 2026
Full QC panel · third-party lab7 assays
Purity (HPLC-UV)99.12% ✓
Identity (LC-MS)Epitalon ✓
HPLC conformity (2×)Confirmed ✓
Net content9.65 mg ✓
Heavy metals (ICP-MS)Not Detected ✓
SterilityNo Growth ✓
Endotoxin (USP <85>)Within limits ✓
Every lot is released against Koi's full QC panel — HPLC purity, LC-MS identity, net content, heavy metals, sterility, and endotoxin — by an independent third-party laboratory (Freedom Diagnostics Testing). Values shown are from the latest released lot and vary batch to batch. The lot-specific certificate is published in our public COA library and matched to the lot ID printed on the vial.
Browse full COA library →
Compound information
Chemical & structural reference data — specifications, molecular profile and handling.
Product Specifications
CompoundEpithalon (synthetic pineal tetrapeptide, AEDG)
Vial size10 mg
Purity≥99% by HPLC
Identity confirmationMass spectrometry
FormWhite to off-white lyophilized powder
Appearance in solutionClear, colorless solution
ManufacturingMade and freeze-dried in the United States
Quality testingIndependent third-party laboratory release (Freedom Diagnostics Testing)
Molecular Profile
SequenceH-Ala-Glu-Asp-Gly-OH
Molecular formulaC₁₄H₂₂N₄O₉
Molecular weight390.35 g/mol
CAS number307297-39-8
PubChem CID219042
Other namesEpitalon, Epithalone, AEDG tetrapeptide
Structure classSynthetic linear tetrapeptide · epithalamin-derived
Storage & Handling
AppearanceWhite to off-white lyophilized powder
SolubilitySterile water · hydrophilic
Storage · powder−20 °C, desiccated, dark (−80 °C long-term)
In solution2–8 °C; aliquot & freeze, avoid freeze-thaw
Epithalon Mechanism of Action
- Activates telomerase, the enzyme that maintains the ends of chromosomes, in cultured human cells with low baseline telomerase activity.
- Associated with telomere elongation in cultured human cells and studied in replicative senescence assays.
- Can bind DNA near the regulatory regions of certain genes, including the telomerase gene, a proposed mechanism for its effects on gene expression.
- Studied for effects on melatonin and cortisol signaling in animal models (results vary by species).
- Studied for effects on reactive oxygen species and DNA-damage markers in cell and animal assays.
Epithalon Research Applications
- Telomerase research in human cells — measuring telomerase activity and telomere length, including work separating the two main routes of telomere elongation.
- Replicative senescence assays in cultured cells.
- Pineal-gland and melatonin signaling research in animal models.
- Telomere and senescence-marker studies in animal models.
- Oxidative-stress assays examining free-radical levels, mitochondrial health, and DNA stability after exposure.
- Comparative work against other short bioregulator peptides to learn how small sequences bind DNA and affect gene activity.
Why Buy Epithalon from Koi Peptides?
- Every batch of Koi epithalon is produced and freeze-dried domestically in the United States, then released against independent third-party laboratory (Freedom Diagnostics Testing) testing.
- Each lot is tested by HPLC for purity, mass spectrometry for identity, and screened for endotoxin before it reaches the catalog.
- The lot ID is printed on every vial and ties back to a public COA library, so researchers can verify documentation before they buy and after the vial arrives.
- Orders placed before 2 PM CT ship the same business day, and shipping is free on orders over $200.
References
The laboratory and preclinical research behind Epithalon — cited for scientific context.
Bull. Exp. Biology & Medicine
Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells
Neuro Endocrinology Letters
DNA double-helix binds regulatory peptides similarly to transcription factors
Biogerontology
Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity
View all references +
- Khavinson, V.Kh., Bondarev, I.E., & Butyugov, A.A. (2003). Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bulletin of Experimental Biology and Medicine, 135(6), 590–592. doi.org/10.1023/A:1025493705728
- Khavinson, V.Kh., Bondarev, I.E., Butyugov, A.A., & Smirnova, T.D. (2004). Peptide promotes overcoming of the division limit in human somatic cell. Bulletin of Experimental Biology and Medicine, 137(5), 503–506.
- Khavinson, V.Kh., Shataeva, L.K., & Chernova, A.A. (2005). DNA double-helix binds regulatory peptides similarly to transcription factors. Neuro Endocrinology Letters, 26(3), 237–241.
- Al-Dulaimi, S., Thomas, R., Matta, S., & Roberts, T. (2025). Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity. Biogerontology. doi.org/10.1007/s10522-025-10315-x
Regulatory Status
Regulatory status — provided for research context.
Regulatory Status
Regulatory status — provided for research context.
FDA Status
Epithalon is not approved by the FDA for any indication. The research-grade material supplied by Koi Peptides is synthesized for laboratory research only; it is not formulated, packaged or labeled as a drug, food or cosmetic.
Disclaimer
For laboratory and research use only. Not for human consumption. This product is not a drug, food or cosmetic. It is sold exclusively to qualified researchers and licensed laboratories. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Frequently Asked Questions About Epithalon
What is Epithalon studied for in research?+
Epithalon is used mainly as a reference peptide in telomere and pineal research. In vitro studies measure its effect on telomerase activity and telomere length in human fibroblasts and cell lines. Animal studies look at melatonin and circadian signaling, telomere and senescence markers, and oxidative-stress markers.
What purity is Koi's Epithalon?+
≥99% by HPLC (latest lot 99.12%), with identity confirmed by mass spectrometry. An independent third-party lab clears each batch, and its COA is published in our public COA library under the same lot number printed on the vial.
How do I prepare an Epithalon solution?+
Because the peptide is water-soluble, plain sterile water dissolves it cleanly — no low-pH solvent needed. Prepare working stock at the concentration your assay calls for, then carry it into buffer or medium just before use. Filter through a 0.22 µm low-protein-binding membrane for sterile cell work, and store prepared solutions at 2–8 °C or aliquot and freeze.
What is the CAS number for Epithalon?+
CAS 307297-39-8, PubChem CID 219042. The molecular formula is C₁₄H₂₂N₄O₉ and the molecular weight is 390.35 g/mol. You may also see it written as Epitalon or Epithalone (sequence Ala-Glu-Asp-Gly).
Is Epithalon the same thing as epithalamin?+
No. Epithalamin is the original crude peptide extract from pineal tissue, made of many components. Epithalon is a single defined tetrapeptide (Ala-Glu-Asp-Gly) drawn from that extract and produced by synthesis. They share an origin, but epithalon is one precise molecule rather than a mixture.
How should Epithalon be stored?+
Keep the powder frozen at −20 °C, sealed and dark, or at −80 °C for the long haul. Once dissolved, hold the solution at 2–8 °C for near-term work or freeze portions at −20 °C or below. Repeated freezing and thawing wear the peptide down, so limit those cycles.
Does Epithalon come with a Certificate of Analysis?+
Yes. Each lot carries its own COA recording HPLC purity, mass-spec identity, and endotoxin results. The full COA library is hosted on our site, indexed by lot ID, so you can pull the document that matches your vial and verify it online at any time.
Is Epithalon for human use?+
No. Epithalon is for laboratory and research use only and is not for human consumption. It is sold exclusively to qualified researchers and licensed laboratories.
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