Made in USA · ≥99% HPLC
Metabolic Peptide
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GLP 2(TZ)
LY3298176Dual GIP/GLP-1 agonistTwincretin
A synthetic dual GIP and GLP-1 receptor agonist (39-amino-acid incretin analog), supplied as sterile lyophilized powder for in-vitro metabolic research.
Price range: $89.95 through $239.95
In stock
For laboratory and research use only. Not for human consumption.
This product is not a drug, food or cosmetic. It is sold exclusively to qualified researchers and licensed laboratories.
Tested by Freedom Diagnostics TestingHPLC purity + LC-MS identityLot-matched COA on-site
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Verified COA
Batch-tested & posted · Freedom Diagnostics
Purity (HPLC-UV)99.883%
Identity (LC-MS)Confirmed
Net content15.77 mg
ReportedApr 5, 2026
US-synthesizedMade & lab-released in the United States
Independent COAThird-party Certificate of Analysis per lot
HPLC + LC-MSPurity by HPLC, identity by mass spectrometry
Same-day dispatchOrders before 2 PM CT ship the same business day
What is GLP-2 (Triz)?
GLP-2 (Triz) (development code LY3298176, often called a "twincretin") is a synthetic single-molecule dual agonist that activates two incretin hormone receptors at once — the GIP receptor and the GLP-1 receptor. A C20 fatty-diacid moiety enables reversible serum-albumin binding and a markedly extended half-life relative to native incretins, and the balanced dual-receptor activity is what distinguishes it from single GLP-1 agonists like GLP-1 (Sema) and from the triple agonist GLP-3 (Reta).
Research areas where laboratories buy GLP-2 (Triz) for in vitro work include GIP- and GLP-1-receptor binding and cAMP-accumulation assays in receptor-expressing cells, glucose-dependent insulin-secretion studies in pancreatic beta-cell models, comparative single- versus dual-incretin agonist pharmacology, metabolic-flux research in rodent models, and albumin-binding and half-life characterization of fatty-acylated incretin analogs.
Every lot, independently verified
Independently third-party tested and matched to the lot ID printed on your vial. Values below are from the latest released lot.
99.88%
HPLC-UV Purity
Passed full QC panel
Independent third-party lab (Freedom Diagnostics Testing)
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Latest batch · tested 5 Apr 2026 · Freedom Diagnostics (USA)
Lot details
ProductGLP-2 (Triz) 15 mg
Lot42206TZ
AppearanceWhite lyophilized powder
Accession #2604030184
Reported5 Apr 2026
Full QC panel · third-party lab7 assays
Purity (HPLC-UV)99.88% ✓
Identity (LC-MS)GLP/GLP-2 (Triz) ✓
HPLC conformity (2×)Confirmed ✓
Net content15.77 mg ✓
Heavy metals (ICP-MS)Not Detected ✓
SterilityNo Growth ✓
Endotoxin (USP <85>)Within limits ✓
Every lot is released against Koi's full QC panel — HPLC purity, LC-MS identity, net content, heavy metals, sterility, and endotoxin — by an independent third-party laboratory (Freedom Diagnostics Testing). Values shown are from the latest released lot and vary batch to batch; per-test results are recorded in each lot's release documentation and matched to the lot ID printed on the vial.
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Compound information
Chemical & structural reference data — specifications, molecular profile and handling.
Product Specifications
CompoundGLP-2 (Triz) (synthetic dual GIP/GLP-1 receptor agonist, lipidated)
Vial size10 mg, 15 mg & 30 mg
Purity≥99% by HPLC
Identity confirmationMass spectrometry
FormLyophilized white to off-white powder
Appearance in solutionClear, colorless solution
ManufacturingSynthesized and lyophilized in the United States
Quality testingIndependent third-party laboratory release (Freedom Diagnostics Testing)
Molecular Profile
ClassDual GIP / GLP-1 receptor agonist
Backbone39-amino-acid incretin analog · C20 fatty-diacid
Molecular formulaC225H348N48O68
Molecular weight≈ 4813.5 g/mol
CAS number2023788-19-2
Other namesLY3298176 · 'twincretin'
Structure class39-amino-acid lipidated dual-receptor incretin peptide; C20 fatty-diacid side chain enabling albumin binding and extended half-life
Storage & Handling
AppearanceWhite lyophilized powder
SolubilitySterile water or buffer · neutral pH
Storage · powder−20 °C, desiccated, dark (−80 °C long-term)
In solution2–8 °C; aliquot & freeze, avoid freeze-thaw
GLP-2 (Triz) Mechanism of Action
- Acts as a balanced agonist at both the GIP and GLP-1 incretin receptors — the basis for the "twincretin" classification.
- Engages Gαs / adenylyl-cyclase / cAMP signaling at each receptor in receptor-expressing cell models.
- Potentiates glucose-dependent insulin secretion in pancreatic beta-cell models.
- Modulates glucagon dynamics and downstream metabolic-flux readouts in cell and rodent systems.
- Carries a C20 fatty-diacid moiety that enables reversible serum-albumin binding and an extended half-life relative to native incretins.
- Serves as the reference dual-incretin tool compound for comparing single- versus dual-receptor pharmacology.
GLP-2 (Triz) Research Applications
- GIP and GLP-1 receptor binding and cAMP-accumulation assays in receptor-expressing cells, where GLP-2 (Triz) is the standard reference dual agonist.
- Glucose-dependent insulin-secretion studies in pancreatic beta-cell models.
- Comparative single- versus dual-incretin agonist pharmacology, run alongside GLP-1 (Sema) (single) and GLP-3 (Reta) (triple) to dissect receptor-specific effects.
- Metabolic-flux rodent research models.
- Albumin-binding and half-life characterization of fatty-acylated incretin analogs.
- Structure-activity studies of dual-receptor incretin peptides.
Why Buy GLP-2 (Triz) from Koi Peptides?
- Every batch of Koi GLP-2 (Triz) is synthesized and lyophilized in the United States, then released against independent third-party laboratory (Freedom Diagnostics Testing) testing.
- Each lot is tested by HPLC for purity, LC-MS for identity confirmation, and screened for endotoxin before release.
- The lot ID is printed on every vial and ties back to a public COA library, so researchers can verify documentation before they buy and after the vial arrives.
- Orders placed before 2 PM CT ship the same business day, and shipping is free on orders over $200.
References
The laboratory and preclinical research behind GLP-2 (Triz) — cited for scientific context.
JCI Insight
GLP-2 (Triz) is an imbalanced and biased dual GIP and GLP-1 receptor agonist
Molecular Metabolism
Glucagon-like peptide 1 (GLP-1)
View all references +
- Willard, F. S., et al. (2020). GLP-2 (Triz) is an imbalanced and biased dual GIP and GLP-1 receptor agonist. JCI Insight, 5(17), e140532. doi.org/10.1172/jci.insight.140532
- Müller, T. D., et al. (2019). Glucagon-like peptide 1 (GLP-1). Molecular Metabolism, 30, 72–130. doi.org/10.1016/j.molmet.2019.09.010
Regulatory Status
Regulatory status — provided for research context.
Regulatory Status
Regulatory status — provided for research context.
Research Use
The GLP-2 (Triz) supplied by Koi Peptides is a research-grade reagent synthesized for laboratory research only. It is not formulated, packaged or labeled as a drug, food or cosmetic, and is not authorized for any human or veterinary use.
Disclaimer
For laboratory and research use only. Not for human consumption. This product is not a drug, food or cosmetic. It is sold exclusively to qualified researchers and licensed laboratories. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Frequently Asked Questions About GLP-2 (Triz)
What is GLP-2 (Triz) used for in research?+
GLP-2 (Triz) is the reference dual GIP/GLP-1 incretin-receptor agonist for studying dual-receptor pharmacology, glucose-dependent insulin secretion, and metabolic flux. In vitro studies use it in receptor-activation assays, pancreatic beta-cell models, and comparative single- versus dual-agonist experiments. Comparative work pairs it against GLP-1 (Sema) (single agonist) and GLP-3 (Reta) (triple agonist) to isolate the GIP-receptor contribution.
What purity is Koi's GLP-2 (Triz)?+
Koi GLP-2 (Triz) is ≥99% pure by HPLC (latest released lot 99.88%), with identity confirmed by LC-MS. Every lot is released against independent third-party laboratory (Freedom Diagnostics Testing) testing covering HPLC purity, LC-MS identity, net content, heavy metals, sterility, and endotoxin, and the COA is published against the lot number printed on the vial.
How do I prepare a GLP-2 (Triz) solution?+
Dissolve in sterile water or a suitable buffer at neutral pH. Add diluent slowly down the vial wall rather than onto the cake, and avoid vortexing. Prepare working dilutions immediately before use, and for sterile cell-culture work filter through a 0.22 µm low-protein-binding filter. Store prepared solutions at 2 to 8 °C, or aliquot and freeze at −20 °C or below.
What is the CAS number for GLP-2 (Triz)?+
The CAS number for GLP-2 (Triz) is 2023788-19-2. It is also cataloged under the Eli Lilly development code LY3298176 and nicknamed the "twincretin." It is a fatty-acylated 39-amino-acid dual GIP/GLP-1 receptor agonist with a molecular weight of approximately 4813.5 g/mol.
Is GLP-2 (Triz) for human use?+
No. GLP-2 (Triz) is for laboratory and research use only and is not for human consumption. It is sold exclusively to qualified researchers and licensed laboratories.
How should GLP-2 (Triz) be stored?+
Store the lyophilized powder at −20 °C, desiccated and protected from light; for long-term storage −80 °C is preferred. Minimize handling time outside the freezer. Once dissolved, store at 2 to 8 °C or aliquot and freeze. Avoid repeated freeze-thaw cycles, which can promote aggregation in lipidated peptides.
How does GLP-2 (Triz) compare with GLP-1 (Sema) and GLP-3 (Reta) as a research tool?+
GLP-1 (Sema) is a single GLP-1 receptor agonist, GLP-2 (Triz) is a dual GLP-1R/GIPR agonist, and GLP-3 (Reta) adds glucagon-receptor activity to become a triple GLP-1R/GIPR/GCGR agonist. Researchers studying receptor-specific contributions often run all three compounds in parallel to isolate the activity of each individual receptor in incretin and metabolic signaling networks.
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