Made in USA · ≥99% HPLC
Ghrelin-Receptor Agonist
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Ipamorelin 10mg & 5mg
GHS-R1a agonistAib-His-D-2-Nal-D-Phe-Lys-NH₂Selective GHRP
A selective growth-hormone-releasing pentapeptide (ghrelin/GHS-R1a agonist), supplied as sterile lyophilized powder for in-vitro endocrinology research.
Price range: $69.95 through $99.95
In stock
For laboratory and research use only. Not for human consumption.
This product is not a drug, food or cosmetic. It is sold exclusively to qualified researchers and licensed laboratories.
Tested by Freedom Diagnostics TestingHPLC purity + LC-MS identityLot-matched COA on-site
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Verified COA
Batch-tested & posted · Freedom Diagnostics
Purity (HPLC-UV)99.84%
Identity (LC-MS)Confirmed
Net content10.13 mg
ReportedJun 20, 2026
US-synthesizedMade & lab-released in the United States
Independent COAThird-party Certificate of Analysis per lot
HPLC + LC-MSPurity by HPLC, identity by mass spectrometry
Same-day dispatchOrders before 2 PM CT ship the same business day
What is Ipamorelin?
Ipamorelin is a synthetic pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH₂) that acts as a selective agonist of the growth-hormone secretagogue receptor (GHS-R1a, the ghrelin receptor). It stimulates pulsatile growth-hormone release from pituitary somatotrophs without significant effect on ACTH, cortisol or prolactin in published models — the basis for its classification as a ‘selective GHRP’.
Research areas where laboratories buy ipamorelin for in vitro work include GHS-R1a receptor-binding and activation assays in receptor-expressing cell lines, pituitary somatotroph GH-release studies in cell-culture and rodent models, comparative GHRP-versus-GHRH secretagogue synergy experiments, and calcium-mobilization and Gq/PLC signaling assays. The material supplied here is research-grade for in vitro laboratory study only.
Every lot, independently verified
Independently third-party tested and matched to the lot ID printed on your vial. Values below are from the latest released lot.
99.84%
HPLC-UV Purity
Passed full QC panel
Independent third-party lab (Freedom Diagnostics Testing)
View COA (PDF)
Latest batch · tested 20 Jun 2026 · Freedom Diagnostics (USA)
Lot details
ProductIpamorelin 10 mg
LotPer-batch on COA
AppearanceWhite lyophilized powder
Accession #2606170096
Reported20 Jun 2026
Full QC panel · third-party lab7 assays
Purity (HPLC-UV)99.84% ✓
Identity (LC-MS)Ipamorelin ✓
HPLC conformity (2×)Confirmed ✓
Net content10.13 mg ✓
Heavy metals (ICP-MS)Not Detected ✓
SterilityNo Growth ✓
Endotoxin (USP <85>)Within limits ✓
Every lot is released against Koi's full QC panel — HPLC purity, LC-MS identity, net content, heavy metals, sterility, and endotoxin — by an independent third-party laboratory (Freedom Diagnostics Testing). Values shown are from the latest released lot and vary batch to batch. The lot-specific certificate is published in our public COA library and matched to the lot ID printed on the vial.
Browse full COA library →
Compound information
Chemical & structural reference data — specifications, molecular profile and handling.
Product Specifications
CompoundIpamorelin (selective GHS-R1a pentapeptide agonist)
Vial size10 mg
Purity≥99% by HPLC
Identity confirmationMass spectrometry
FormWhite lyophilized powder
Appearance in solutionClear, colorless solution
ManufacturingSynthesized and lyophilized in the United States
Quality testingIndependent third-party laboratory release (Freedom Diagnostics Testing)
Molecular Profile
SequenceAib-His-D-2-Nal-D-Phe-Lys-NH₂
Molecular formulaC38H49N9O5
Molecular weight711.85 g/mol
CAS number170851-70-4
ReceptorGHS-R1a (ghrelin)
Structure classSynthetic pentapeptide GHRP
Storage & Handling
AppearanceWhite lyophilized powder
SolubilitySterile water · neutral pH
Storage · powder−20 °C, desiccated, dark (−80 °C long-term)
In solution2–8 °C; aliquot & freeze, avoid freeze-thaw
Ipamorelin Mechanism of Action
- Acts as a selective agonist of the growth-hormone secretagogue receptor (GHS-R1a, the ghrelin receptor) on pituitary somatotrophs.
- Stimulates pulsatile growth-hormone release without significant effect on ACTH, cortisol, or prolactin in published models — the basis for its ‘selective GHRP’ classification.
- Synergizes with GHRH-receptor agonists (e.g. CJC-1295, sermorelin) on GH release in paired secretagogue studies.
- Acts through Gq/PLC signaling and intracellular calcium mobilization in receptor-expressing cell models.
- The Aib and D-amino-acid residues confer protease resistance relative to native ghrelin-derived sequences.
- Carries no melanocortin or opioid receptor activity, isolating GHS-R1a pharmacology as a research tool.
Ipamorelin Research Applications
- GHS-R1a receptor-binding and activation assays in receptor-expressing cell lines.
- Pituitary somatotroph GH-release studies in cell-culture and rodent models.
- Comparative GHRP vs GHRH secretagogue synergy experiments.
- Calcium-mobilization and Gq/PLC signaling assays.
- Selectivity profiling against ACTH, cortisol, and prolactin readouts.
- Structure-activity studies of GHS-R1a pentapeptide agonists.
Why Buy Ipamorelin from Koi Peptides?
- Every batch of Koi ipamorelin is synthesized and lyophilized in the United States, then released against independent third-party laboratory (Freedom Diagnostics Testing) testing.
- Each lot is tested by HPLC for purity, LC-MS for identity confirmation, and screened for endotoxin before release.
- The lot ID is printed on every vial and ties back to a public COA library, so researchers can verify documentation before they buy and after the vial arrives.
- Orders placed before 2 PM CT ship the same business day, and shipping is free on orders over $200.
References
The laboratory and preclinical research behind Ipamorelin — cited for scientific context.
Eur. J. Endocrinology
Ipamorelin, the first selective growth hormone secretagogue
Endocrine Reviews
Ghrelin and the growth hormone secretagogue receptor
Cell
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
View all references +
- Raun, K., et al. (1998). Ipamorelin, the first selective growth hormone secretagogue. European Journal of Endocrinology, 139(5), 552–561. doi.org/10.1530/eje.0.1390552
- Kojima, M., & Kangawa, K. (2005). Ghrelin: structure and function. Endocrine Reviews / Physiological Reviews, 85(2), 495–522. doi.org/10.1210/er.2004-0014
- Kojima, M., et al. (1999). Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature, 402(6762), 656–660. doi.org/10.1038/45230
Regulatory Status
Regulatory status — provided for research context.
Regulatory Status
Regulatory status — provided for research context.
Research Use
This research-grade material is supplied by Koi Peptides for laboratory research only. It is not approved by the FDA for any indication, and is not formulated, packaged or labeled as a drug, food or cosmetic.
Disclaimer
For laboratory and research use only. Not for human consumption. This product is not a drug, food or cosmetic. It is sold exclusively to qualified researchers and licensed laboratories. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Frequently Asked Questions About Ipamorelin
What is Ipamorelin used for in research?+
Ipamorelin is the reference selective ghrelin-receptor (GHS-R1a) agonist for studying pituitary GH release without the ACTH/cortisol/prolactin effects of older secretagogues. It is used in receptor-binding assays, somatotroph GH-release models, and GHRP/GHRH synergy experiments.
What purity is Koi's Ipamorelin?+
≥99% by HPLC (latest lot 99.84%), with identity confirmed by LC-MS. Every lot is released against third-party testing for HPLC purity, LC-MS identity, net content, heavy metals, sterility, and endotoxin. The lot-specific COA is published in our public COA library and matched to the lot number printed on the vial.
How do I prepare a solution of Ipamorelin?+
Dissolve in sterile water at neutral pH. Add diluent down the vial wall, allow the cake to dissolve without vortexing, and prepare working dilutions before use; filter through 0.22 µm for sterile cell-culture work. Store prepared solutions at 2–8 °C or aliquot and freeze.
What is the CAS number for Ipamorelin?+
CAS 170851-70-4. The pentapeptide is Aib-His-D-2-Nal-D-Phe-Lys-NH₂, molecular weight 711.85 g/mol, molecular formula C38H49N9O5.
How is Ipamorelin selective compared with other GHRPs?+
Ipamorelin stimulates GH release through GHS-R1a but, unlike earlier growth-hormone-releasing peptides, shows little effect on ACTH, cortisol or prolactin in published models. It also carries no melanocortin or opioid receptor activity, which is why it is used as a clean GHS-R1a tool compound.
How should Ipamorelin be stored?+
Store the lyophilized powder at −20 °C, desiccated and protected from light; for long-term storage −80 °C is preferred. Once dissolved, store at 2–8 °C or aliquot and freeze, and avoid repeated freeze-thaw cycles.
Does Ipamorelin come with a Certificate of Analysis?+
Yes. The lot-specific Certificate of Analysis covering HPLC purity, LC-MS identity, net content, heavy metals, sterility and endotoxin is published in our public COA library and matched to the lot ID printed on the vial.
Is Ipamorelin for human use?+
No. This product is for laboratory and research use only and is not for human consumption. It is sold exclusively to qualified researchers and licensed laboratories.
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