Made in USA · ≥99% HPLC
KISS1R Agonist
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Kisspeptin-10 10mg & 5mg (Kp-10)
Kp-10Metastin (45-54)KISS1R / GPR54 agonist
A KISS1-derived decapeptide (Kp-10) that activates the KISS1R (GPR54) receptor upstream of GnRH, supplied as 5 mg sterile lyophilized powder for in-vitro reproductive-endocrinology research.
Price range: $54.95 through $89.95
In stock
For laboratory and research use only. Not for human consumption.
This product is not a drug, food or cosmetic. It is sold exclusively to qualified researchers and licensed laboratories.
Tested by Freedom Diagnostics TestingHPLC purity + LC-MS identityLot-matched COA on-site
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Verified COA
Batch-tested & posted · Freedom Diagnostics
Purity (HPLC-UV)99.256%
Identity (LC-MS)Confirmed
Net content5.09 mg
ReportedMar 23, 2026
US-synthesizedMade & lab-released in the United States
Independent COAThird-party Certificate of Analysis per lot
HPLC + LC-MSPurity by HPLC, identity by mass spectrometry
Same-day dispatchOrders before 2 PM CT ship the same business day
What is Kisspeptin-10?
Kisspeptin-10 (Kp-10) is a synthetic decapeptide (Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂) corresponding to the C-terminal active fragment of the KISS1 gene product, also known as metastin. It is an agonist of the KISS1R receptor (GPR54) and retains the full receptor-activating activity of the parent kisspeptin. The C-terminal Arg-Phe-NH₂ (RFamide) motif is essential for receptor activation.
Research areas where laboratories buy kisspeptin-10 for in vitro work include KISS1R (GPR54) binding and calcium-mobilization assays in receptor-expressing cells, GnRH-neuron activation studies in hypothalamic cell-culture and slice models, hypothalamic-pituitary-gonadal (HPG) axis modeling with downstream LH/FSH readouts, and structure-activity studies of the kisspeptin C-terminal RFamide motif. Kisspeptin remains an investigational compound in reproductive-endocrinology research; the material supplied here is research-grade for in vitro laboratory study only.
Every lot, independently verified
Independently third-party tested and matched to the lot ID printed on your vial. Values below are from the latest released lot.
99.26%
HPLC-UV Purity
Passed full QC panel
Independent third-party lab (Freedom Diagnostics Testing)
View COA (PDF)
Latest batch · tested 23 Mar 2026 · Freedom Diagnostics (USA)
Lot details
ProductKisspeptin-10 5 mg
LotRed Cap
AppearanceWhite lyophilized powder
Accession #2603200302
Reported23 Mar 2026
Full QC panel · third-party lab7 assays
Purity (HPLC-UV)99.26% ✓
Identity (LC-MS)Kisspeptin ✓
HPLC conformity (2×)Confirmed ✓
Net content5.09 mg ✓
Heavy metals (ICP-MS)Not Detected ✓
SterilityNo Growth ✓
Endotoxin (USP <85>)Within limits ✓
Every lot is released against Koi's full QC panel — HPLC purity, LC-MS identity, net content, heavy metals, sterility, and endotoxin — by an independent third-party laboratory (Freedom Diagnostics Testing). Values shown are from the latest released lot and vary batch to batch. The lot-specific certificate is published in our public COA library and matched to the lot ID printed on the vial.
Browse full COA library →
Compound information
Chemical & structural reference data — specifications, molecular profile and handling.
Product Specifications
CompoundKisspeptin-10 (KISS1R / GPR54 decapeptide agonist)
Vial size5 mg
Purity≥99% by HPLC
Identity confirmationMass spectrometry
FormWhite lyophilized powder
Appearance in solutionClear, colorless solution
ManufacturingSynthesized and lyophilized in the United States
Quality testingIndependent third-party laboratory release (Freedom Diagnostics Testing)
Molecular Profile
SequenceTyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂
FragmentKISS1 (112-121) / metastin (45-54)
Molecular weight1302.5 g/mol
CAS number374675-21-5
ReceptorKISS1R (GPR54)
Structure classDecapeptide · C-terminal amide
Storage & Handling
AppearanceWhite lyophilized powder
SolubilitySterile water · neutral pH
Storage · powder−20 °C, desiccated, dark (−80 °C long-term)
In solution2–8 °C; aliquot & freeze, avoid freeze-thaw
Kisspeptin-10 Mechanism of Action
- Activates the KISS1R (GPR54) receptor — the C-terminal decapeptide retains the full receptor-activating activity of the parent kisspeptin.
- Signals through Gq/PLC, mobilizing intracellular calcium in receptor-expressing cells.
- Acts on hypothalamic GnRH neurons to drive GnRH release, positioning kisspeptin upstream of the hypothalamic-pituitary-gonadal (HPG) axis.
- Drives downstream LH and FSH secretion in physiological models via GnRH.
- The C-terminal Arg-Phe-NH₂ (RFamide) motif is essential for receptor activation.
- Serves as the reference KISS1R agonist for separating kisspeptin-driven from direct GnRH-driven effects.
Kisspeptin-10 Research Applications
- KISS1R (GPR54) binding and calcium-mobilization assays in receptor-expressing cells.
- GnRH-neuron activation studies in hypothalamic cell-culture and slice models.
- HPG-axis modeling — downstream LH/FSH readouts in rodent systems.
- Structure-activity studies of the kisspeptin C-terminal RFamide motif.
- Reproductive-endocrinology and puberty-onset research models.
- Comparative work against full-length kisspeptin-54 and shorter fragments.
Why Buy Kisspeptin-10 from Koi Peptides?
- Every batch of Koi kisspeptin-10 is synthesized and lyophilized in the United States, then released against independent third-party laboratory (Freedom Diagnostics Testing) testing.
- Each lot is tested by HPLC for purity, LC-MS for identity confirmation, and screened for endotoxin before release.
- The lot ID is printed on every vial and ties back to a public COA library, so researchers can verify documentation before they buy and after the vial arrives.
- Orders placed before 2 PM CT ship the same business day, and shipping is free on orders over $200.
References
The laboratory and preclinical research behind Kisspeptin-10 — cited for scientific context.
J. Biological Chemistry
AXOR12, a novel human GPCR activated by the metastasis-suppressor KiSS-1
New England J. of Medicine
The GPR54 gene as a regulator of puberty
Physiological Reviews
Kisspeptins and reproduction: physiological roles & regulatory mechanisms
View all references +
- Muir, A. I., et al. (2001). AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1. Journal of Biological Chemistry, 276(31), 28969–28975. doi.org/10.1074/jbc.M104847200
- Seminara, S. B., et al. (2003). The GPR54 gene as a regulator of puberty. New England Journal of Medicine, 349(17), 1614–1627. doi.org/10.1056/NEJMoa035322
- Pinilla, L., et al. (2012). Kisspeptins and reproduction: physiological roles and regulatory mechanisms. Physiological Reviews, 92(3), 1235–1316. doi.org/10.1152/physrev.00037.2010
Regulatory Status
Regulatory status — provided for research context.
Regulatory Status
Regulatory status — provided for research context.
Research Use
This research-grade material is supplied by Koi Peptides for laboratory research only. It is not approved by the FDA for any indication, and is not formulated, packaged or labeled as a drug, food or cosmetic.
Disclaimer
For laboratory and research use only. Not for human consumption. This product is not a drug, food or cosmetic. It is sold exclusively to qualified researchers and licensed laboratories. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Frequently Asked Questions About Kisspeptin-10
What is Kisspeptin-10 used for in research?+
Kisspeptin-10 (Kp-10) is the reference KISS1R/GPR54 agonist for studying the upstream control of GnRH and the HPG axis. It is used in receptor-activation assays, GnRH-neuron studies, and reproductive-endocrinology models.
What purity is Koi's Kisspeptin-10?+
≥99% by HPLC (latest lot 99.26%), with identity confirmed by LC-MS. Every lot is released against third-party testing for HPLC purity, LC-MS identity, net content, heavy metals, sterility, and endotoxin. The lot-specific COA is published in our public COA library and matched to the lot number printed on the vial.
How do I prepare a solution of Kisspeptin-10?+
Dissolve in sterile water at neutral pH; add diluent down the vial wall and avoid vortexing. Prepare working dilutions before use and filter through 0.22 µm for sterile cell-culture work. Store prepared solutions at 2–8 °C or aliquot and freeze.
What is the CAS number for Kisspeptin-10?+
CAS 374675-21-5. The decapeptide is Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂ (KISS1 112-121 / metastin 45-54), molecular weight ~1302.5 g/mol.
How does Kisspeptin-10 relate to the HPG axis?+
Kisspeptin acts upstream of GnRH: it activates KISS1R on hypothalamic GnRH neurons, driving GnRH release that in turn stimulates downstream LH and FSH secretion. This makes Kp-10 a key tool for separating kisspeptin-driven effects from direct GnRH-driven effects in HPG-axis models.
How should Kisspeptin-10 be stored?+
Store the lyophilized powder at −20 °C, desiccated and protected from light; for long-term storage −80 °C is preferred. Once dissolved, store at 2–8 °C or aliquot and freeze, and avoid repeated freeze-thaw cycles.
Does Kisspeptin-10 come with a Certificate of Analysis?+
Yes. The lot-specific Certificate of Analysis covering HPLC purity, LC-MS identity, net content, heavy metals, sterility and endotoxin is published in our public COA library and matched to the lot ID printed on the vial.
Is Kisspeptin-10 for human use?+
No. This product is for laboratory and research use only and is not for human consumption. It is sold exclusively to qualified researchers and licensed laboratories.
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