A cyclic heptapeptide melanocortin-receptor agonist (an α-MSH analog), supplied as sterile lyophilized powder for in-vitro melanocortin-pathway research.
$39.951 in stock
For laboratory and research use only. Not for human consumption.
This product is not a drug, food or cosmetic. It is sold exclusively to qualified researchers and licensed laboratories.
1 in stock
Tested by Freedom Diagnostics TestingHPLC purity + LC-MS identityLot-matched COA on-site
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US-synthesizedMade & lab-released in the United States
Independent COAThird-party Certificate of Analysis per lot
HPLC + LC-MSPurity by HPLC, identity by mass spectrometry
Same-day dispatchOrders before 2 PM CT ship the same business day
What is PT-141?
PT-141 (bremelanotide) is a cyclic heptapeptide MC4R-preferring melanocortin agonist studied in receptor-signaling assays. It is an analog of α-melanocyte-stimulating hormone (α-MSH) with additional MC1R activity. Its cyclic structure confers receptor selectivity and metabolic stability relative to the linear α-MSH scaffold from which it is derived, and it engages Gs / adenylyl-cyclase / cAMP signaling in receptor-expressing cells. In the laboratory it is widely used as a reference MC4R agonist tool compound.
Research areas where laboratories buy PT-141 for in vitro work include MC4R and MC1R receptor-binding and cAMP-accumulation assays, central melanocortin-system signaling studies in cell and rodent models, receptor-subtype selectivity profiling across MC1R–MC5R, structure-activity studies of cyclic α-MSH analogs, and comparative pharmacology against linear melanocortin peptides.
Every lot, independently verified
Independently third-party tested and matched to the lot ID printed on your vial. Values below are from the latest released lot.
Every lot is released against Koi's full QC panel — HPLC purity, LC-MS identity, heavy metals, sterility, and endotoxin — by an independent third-party laboratory (Freedom Diagnostics Testing). The lot-specific certificate is published in our public COA library and matched to the lot ID printed on the vial.
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Compound information
Chemical & structural reference data — specifications, molecular profile and handling.
Derived from the α-MSH scaffold; the cyclic structure confers receptor selectivity and metabolic stability.
Studied for melanocortin-mediated CNS signaling pathways in preclinical models.
Shows a receptor-subtype selectivity profile distinct from non-selective melanocortin agonists.
Serves as the reference MC4R agonist tool compound for melanocortin pharmacology.
PT-141 Research Applications
MC4R and MC1R receptor binding and cAMP-accumulation assays.
Central melanocortin-system signaling studies in cell and rodent models.
Receptor-subtype selectivity profiling across MC1R–MC5R.
Structure-activity studies of cyclic α-MSH analogs.
Behavioral neuroscience models of melanocortin signaling.
Comparative pharmacology against linear melanocortin peptides.
Why Buy PT-141 from Koi Peptides?
Every batch of Koi PT-141 is synthesized and lyophilized in the United States, then released against independent third-party laboratory (Freedom Diagnostics Testing) testing.
Each lot is tested by HPLC for purity, LC-MS for identity confirmation, and screened for endotoxin before release.
The lot ID is printed on every vial and ties back to a public COA library, so researchers can verify documentation before they buy and after the vial arrives.
Orders placed before 2 PM CT ship the same business day, and shipping is free on orders over $200.
References
The laboratory and preclinical research behind PT-141 (bremelanotide) — cited for scientific context.
Endocrine Reviews
Studies on the physiological functions of the melanocortin system
Cone, R. D. (2006). Studies on the physiological functions of the melanocortin system. Endocrine Reviews, 27(7), 736–749. doi.org/10.1210/er.2006-0034
Yang, Y. (2011). Structure, function and regulation of the melanocortin receptors. European Journal of Pharmacology, 660(1), 125–130. doi.org/10.1016/j.ejphar.2010.12.020
Regulatory Status
Regulatory status — provided for research context.
Research Use
The PT-141 supplied by Koi Peptides is a research-grade reagent synthesized for laboratory research only. It is not formulated, packaged or labeled as a drug, food or cosmetic, and is not authorized for any human or veterinary use.
Disclaimer
For laboratory and research use only. Not for human consumption. This product is not a drug, food or cosmetic. It is sold exclusively to qualified researchers and licensed laboratories. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
PT-141 (bremelanotide) is the reference MC4R melanocortin agonist for studying central melanocortin signaling, receptor-subtype selectivity, and cyclic α-MSH-analog pharmacology in cell and rodent models. In-vitro studies use it in MC4R/MC1R binding and cAMP-accumulation assays and in selectivity profiling across MC1R–MC5R.
What purity is Koi's PT-141?+
Each lot is released at ≥99% by HPLC with LC-MS-confirmed identity, against third-party testing covering HPLC purity, LC-MS identity, heavy metals, sterility, and endotoxin. The lot-matched COA is posted to the public library.
How do I prepare a PT-141 solution?+
Dissolve in sterile water or a suitable buffer at neutral pH. Prepare working dilutions immediately before use, and for sterile cell-culture work filter through a 0.22 µm low-protein-binding membrane.
What is the CAS number for PT-141?+
The CAS number is 189691-06-3 (bremelanotide). It is a cyclic heptapeptide α-MSH analog with molecular formula C50H68N14O10 and a molecular weight of 1025.18 g/mol.
How should PT-141 be stored?+
Hold the lyophilized powder at −20 °C (−80 °C long-term), desiccated and protected from light. Once dissolved, store at 2 to 8 °C, and aliquot/freeze for longer storage to avoid repeated freeze-thaw cycles.
Is PT-141 for human use?+
No. PT-141 is for laboratory and research use only and is not for human consumption. It is sold exclusively to qualified researchers and licensed laboratories.
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