A synthetic seven-residue peptide derived from the immunomodulatory sequence of tuftsin, stabilized by a C-terminal Pro-Gly-Pro motif, supplied as sterile lyophilized powder for in-vitro neuropharmacology research.
$39.958 in stock
For laboratory and research use only. Not for human consumption.
This product is not a drug, food or cosmetic. It is sold exclusively to qualified researchers and licensed laboratories.
8 in stock
Tested by Freedom Diagnostics TestingHPLC purity + LC-MS identityLot-matched COA on-site
US-synthesizedMade & lab-released in the United States
Independent COAThird-party Certificate of Analysis per lot
HPLC + LC-MSPurity by HPLC, identity by mass spectrometry
Same-day dispatchOrders before 2 PM CT ship the same business day
What is Selank?
Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro, or TKPRPGP) derived from the immunopeptide tuftsin. The addition of a C-terminal Pro-Gly-Pro motif confers resistance to enzymatic degradation, extending the molecule's activity relative to the native four-residue tuftsin parent. Developed in Russia, it is studied for GABA-A receptor modulation and immune signaling and is not approved by the FDA for any indication.
Research areas where laboratories buy Selank for in vitro and preclinical work include behavioral models in rodents (elevated plus maze, open field), GABA-A receptor and GABAergic neurotransmission assays, BDNF and neurotrophin expression studies in hippocampal cultures, enkephalinase-inhibition and regulatory-peptide stability assays, immunomodulation studies leveraging the tuftsin parent sequence, and monoamine balance and gene-expression profiling under defined conditions.
Every lot, independently verified
Independently third-party tested and matched to the lot ID printed on your vial. Values below are from the latest released lot.
Every lot is released against Koi's full QC panel — HPLC purity, LC-MS identity, net content, heavy metals, sterility, and endotoxin — by an independent third-party laboratory (Freedom Diagnostics Testing). Values shown are from the latest released lot and vary batch to batch; the lot-specific certificate is published in our public COA library and matched to the lot ID printed on the vial.
Browse full COA library →
Compound information
Chemical & structural reference data — specifications, molecular profile and handling.
Storage · powder−20 °C, desiccated, dark (−80 °C long-term)
In solution2–8 °C; aliquot & freeze, avoid freeze-thaw
Selank Mechanism of Action
Stabilized analog of the immunopeptide tuftsin — the C-terminal Pro-Gly-Pro motif confers resistance to enzymatic degradation, extending activity relative to native tuftsin.
Modulates GABAergic neurotransmission, the proposed basis for its behavioral effects in rodent models.
Influences brain-derived neurotrophic factor (BDNF) expression in hippocampal tissue.
Inhibits enkephalin-degrading enzymes, prolonging the activity of endogenous regulatory peptides.
Modulates monoamine (serotonin/dopamine) balance and expression of inflammation- and immunity-related genes.
Retains tuftsin-like immunomodulatory activity.
Selank Research Applications
Behavioral models in rodents (elevated plus maze, open field).
GABA-A receptor and GABAergic neurotransmission assays.
BDNF and neurotrophin expression studies in hippocampal cultures.
Enkephalinase-inhibition and regulatory-peptide stability assays.
Immunomodulation studies leveraging the tuftsin parent sequence.
Monoamine balance and gene-expression profiling under defined conditions.
Why Buy Selank from Koi Peptides?
Every batch of Koi Selank is synthesized and lyophilized in the United States, then released against independent third-party laboratory (Freedom Diagnostics Testing) testing.
Each lot is tested by HPLC for purity, LC-MS for identity confirmation, and screened for endotoxin before release.
The lot ID is printed on every vial and ties back to a public COA library, so researchers can verify documentation before they buy and after the vial arrives.
Orders placed before 2 PM CT ship the same business day, and shipping is free on orders over $200.
References
The laboratory and preclinical research behind Selank — cited for scientific context.
J. Psychopharmacology
Selank and its effect on the GABAergic and monoaminergic systems
Volkova A. et al. · 2016
Peptides
Effect of Selank on gene expression of inflammation and immunity in rat brain
Kolomin T. et al. · 2014
View all 2 references +
Volkova, A., et al. (2016). Selank and its effect on the GABAergic and monoaminergic systems. Journal of Psychopharmacology.
Kolomin, T., et al. (2014). Effect of Selank on gene expression of inflammation and immunity in rat brain. Peptides.
Regulatory Status
Regulatory status — provided for research context.
FDA Status
Selank is not approved by the FDA for any indication. The research-grade material supplied by Koi Peptides is synthesized for laboratory research only; it is not formulated, packaged or labeled as a drug, food or cosmetic.
Disclaimer
For laboratory and research use only. Not for human consumption. This product is not a drug, food or cosmetic. It is sold exclusively to qualified researchers and licensed laboratories. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Selank is studied for GABA-A receptor modulation and immune signaling. In-vitro and preclinical work uses it in rodent behavioral models (elevated plus maze, open field), GABA-A receptor and GABAergic neurotransmission assays, BDNF and neurotrophin expression studies, and immunomodulation studies leveraging the tuftsin parent sequence.
What is Selank?+
A synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) derived from the immunopeptide tuftsin, with a C-terminal Pro-Gly-Pro motif for stability. It was developed in Russia and is studied for GABA-A receptor modulation and immune signaling.
What purity is Koi's Selank?+
HPLC-verified with LC-MS-confirmed identity — the latest released lot tested 99.88%. Every lot is released against third-party testing for HPLC purity, LC-MS identity, net content, heavy metals, sterility, and endotoxin, with a public lot-matched COA.
How do I prepare a Selank solution?+
Dissolve in sterile water at neutral pH — Selank is water-soluble and requires no cosolvent. Prepare working dilutions immediately before use; for sterile cell-culture work, filter through a 0.22 µm low-protein-binding membrane.
What is the CAS number for Selank?+
The CAS number is 129954-34-3. The molecule is the tuftsin-derived heptapeptide TKPRPGP (molecular formula C33H57N11O9, molecular weight 751.90 g/mol).
How should Selank be stored?+
Hold the lyophilized powder at −20 °C (−80 °C long-term), desiccated and protected from light. Once dissolved, store at 2 to 8 °C, and aliquot/freeze for longer storage to avoid repeated freeze-thaw cycles.
Is Selank for human use?+
No. Selank is for laboratory and research use only and is not for human consumption. It is sold exclusively to qualified researchers and licensed laboratories.
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