Made in USA · ≥99% HPLC
Neuropeptide
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Semax
ACTH(4-10) analogMEHFPGPHeptapeptide
A synthetic heptapeptide analog of the ACTH(4-10) fragment, stabilized by a C-terminal Pro-Gly-Pro motif, supplied as 10 mg of sterile lyophilized powder for in-vitro neuropharmacology research.
$39.95
16 in stock
For laboratory and research use only. Not for human consumption.
This product is not a drug, food or cosmetic. It is sold exclusively to qualified researchers and licensed laboratories.
16 in stock
Tested by Freedom Diagnostics TestingHPLC purity + LC-MS identityLot-matched COA on-site
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Verified COA
Batch-tested & posted · Freedom Diagnostics
Purity (HPLC-UV)98.957%
Identity (LC-MS)Confirmed
Net content11.80 mg
ReportedApr 5, 2026
US-synthesizedMade & lab-released in the United States
Independent COAThird-party Certificate of Analysis per lot
HPLC + LC-MSPurity by HPLC, identity by mass spectrometry
Same-day dispatchOrders before 2 PM CT ship the same business day
What is Semax?
Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) analog of the ACTH(4-10) fragment, stabilized by a C-terminal Pro-Gly-Pro motif that confers resistance to enzymatic degradation. Originally developed in Russia, it is studied for BDNF and TrkB signaling and lacks the steroidogenic and melanocortin activity of full ACTH, isolating the neurotropic activity of the (4-10) fragment as a research tool.
Research areas where laboratories buy Semax for in vitro work include brain-derived neurotrophic factor (BDNF) and TrkB expression studies in hippocampal and basal-forebrain cultures, cerebral ischemia models and behavioral endpoints in rodent models, dopaminergic and serotonergic neurotransmission assays, and oxidative-stress and neuroinflammation models in cell culture. Semax is not approved by the FDA for any indication.
Every lot, independently verified
Independently third-party tested and matched to the lot ID printed on your vial. Values below are from the latest released lot.
98.96%
HPLC-UV Purity
Passed full QC panel
Independent third-party lab (Freedom Diagnostics Testing)
View COA (PDF)
Latest batch · tested 5 Apr 2026 · Freedom Diagnostics (USA)
Lot details
ProductSemax 11 mg
Lot42206SM
AppearanceWhite lyophilized powder
Accession #2604030181
Reported5 Apr 2026
Full QC panel · third-party lab7 assays
Purity (HPLC-UV)98.957% ✓
Identity (LC-MS)Semax ✓
HPLC conformity (2×)Confirmed ✓
Net content11.80 mg ✓
Heavy metals (ICP-MS)Not Detected ✓
SterilityNo Growth ✓
Endotoxin (USP <85>)Within limits ✓
Every lot is released against Koi's full QC panel — HPLC purity, LC-MS identity, net content, heavy metals, sterility, and endotoxin — by an independent third-party laboratory (Freedom Diagnostics Testing). Values shown are from the latest released lot (Lot 42206SM, reported 5 Apr 2026) and vary batch to batch; the lot-specific certificate is published in our public COA library and matched to the lot ID printed on the vial.
Browse full COA library →
Compound information
Chemical & structural reference data — specifications, molecular profile and handling.
Product Specifications
CompoundSemax (synthetic ACTH(4-10) heptapeptide analog)
Vial size11 mg
Purity≥98% by HPLC
Identity confirmationMass spectrometry
FormWhite lyophilized powder
Appearance in solutionClear, colorless solution
ManufacturingSynthesized and lyophilized in the United States
Quality testingIndependent third-party laboratory release (Freedom Diagnostics Testing)
Molecular Profile
SequenceMet-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP)
Molecular formulaC39H54N10O10S
Molecular weight813.97 g/mol
CAS number80714-61-0
PubChem CID9811062
ParentACTH(4-10) fragment
Structure classSynthetic heptapeptide · Pro-Gly-Pro stabilized
Storage & Handling
AppearanceWhite lyophilized powder
SolubilitySterile water · neutral pH
Storage · powder−20 °C, desiccated, dark (−80 °C long-term)
In solution2–8 °C; aliquot & freeze, avoid freeze-thaw
Semax Mechanism of Action
- Acts as a stable analog of the ACTH(4-10) fragment — the C-terminal Pro-Gly-Pro motif confers resistance to enzymatic degradation, extending activity relative to the native fragment.
- Upregulates brain-derived neurotrophic factor (BDNF) and its receptor TrkB in hippocampal tissue in rodent and cell-culture models.
- Modulates dopaminergic and serotonergic neurotransmission, the basis for much of the published neuropharmacology work.
- Inhibits enkephalin-degrading enzymes, prolonging the activity of endogenous regulatory peptides.
- Studied for effects on oxidative-stress and inflammatory signaling in cerebral ischemia models.
- Lacks the steroidogenic / melanocortin activity of full ACTH, isolating the neurotropic activity of the (4-10) fragment as a research tool.
Semax Research Applications
- BDNF and TrkB expression studies in hippocampal and basal-forebrain cultures.
- Cerebral ischemia rodent models.
- Behavioral endpoints in rodent models.
- Dopaminergic and serotonergic neurotransmission assays.
- Oxidative-stress and neuroinflammation models in cell culture.
- Enzymatic-stability and structure-activity studies of the Pro-Gly-Pro–stabilized heptapeptide.
Why Buy Semax from Koi Peptides?
- Every batch of Koi Semax is synthesized and lyophilized in the United States, then released against independent third-party laboratory (Freedom Diagnostics Testing) testing.
- Each lot is tested by HPLC for purity, LC-MS for identity confirmation, and screened for endotoxin before release.
- The lot ID is printed on every vial and ties back to a public COA library, so researchers can verify documentation before they buy and after the vial arrives.
- Orders placed before 2 PM CT ship the same business day, and shipping is free on orders over $200.
References
The laboratory and preclinical research behind Semax — cited for scientific context.
Biochemistry (Moscow)
Semax, an ACTH(4-10) analogue, activates dopaminergic and serotoninergic brain systems
Neuroscience Letters
Semax, an analog of ACTH(4-10), stimulates expression of BDNF and trkB in rat basal forebrain
Neuroscience Letters
Rapid induction of neurotrophin mRNAs by the neuropeptide Semax
View all references +
- Medvedeva, E. V., et al. (2014). Semax, an ACTH(4-10) analogue, activates dopaminergic and serotoninergic brain systems. Biochemistry (Moscow), 79(3), 209–216. doi.org/10.1134/S0006297914030092
- Dolotov, O. V., et al. (2006). Semax, an analog of ACTH(4-10), stimulates expression of BDNF and trkB in rat basal forebrain. Neuroscience Letters, 396(2), 163–167.
- Shadrina, M. I., et al. (2010). Rapid induction of neurotrophin mRNAs by the neuropeptide Semax. Neuroscience Letters, 471(1), 37–41.
Regulatory Status
Regulatory status — provided for research context.
Regulatory Status
Regulatory status — provided for research context.
FDA Status
Semax is not approved by the FDA for any indication. The research-grade material supplied by Koi Peptides is synthesized for laboratory research only; it is not formulated, packaged or labeled as a drug, food or cosmetic.
Disclaimer
For laboratory and research use only. Not for human consumption. This product is not a drug, food or cosmetic. It is sold exclusively to qualified researchers and licensed laboratories. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Frequently Asked Questions About Semax
What is Semax used for in research?+
Semax is studied for BDNF and TrkB signaling. In vitro work covers BDNF and TrkB expression studies in hippocampal and basal-forebrain cultures, dopaminergic and serotonergic neurotransmission assays, and oxidative-stress and neuroinflammation models in cell culture. Rodent studies use cerebral ischemia models and behavioral endpoints.
What purity is Koi's Semax?+
Koi Semax is HPLC-verified with LC-MS-confirmed identity — the latest released lot tested 98.96% by HPLC-UV. Every lot is released against third-party testing covering HPLC purity, LC-MS identity, net content, heavy metals, sterility, and endotoxin, and the COA is published against the lot number printed on the vial.
How do I prepare a Semax solution?+
Dissolve in sterile water at neutral pH — Semax is water-soluble and requires no organic cosolvent. Prepare working dilutions before use; for sterile cell-culture work, filter through a 0.22 µm low-protein-binding membrane. Store prepared solutions at 2 to 8 °C, or aliquot and freeze at −20 °C or below.
What is the CAS number for Semax?+
The CAS number for Semax is 80714-61-0 and the PubChem CID is 9811062. The molecule is also described as the ACTH(4-10) Pro-Gly-Pro analog (MEHFPGP), with a molecular weight of 813.97 g/mol.
Is Semax for human use?+
No. Semax is for laboratory and research use only and is not for human consumption. It is sold exclusively to qualified researchers and licensed laboratories.
Does Semax come with a Certificate of Analysis?+
Yes. The lot-specific Certificate of Analysis is published in our public COA library and matched to the lot ID printed on the vial. It covers HPLC purity, LC-MS identity, net content, heavy metals, sterility, and endotoxin, so researchers can verify documentation before they buy and after the vial arrives.
How should Semax be stored?+
Store the lyophilized powder at −20 °C, desiccated and protected from light; for long-term storage −80 °C is preferred. Once dissolved, store at 2 to 8 °C or aliquot and freeze. Avoid repeated freeze-thaw cycles.
Is Semax FDA-approved?+
No. Semax is not approved by the FDA for any indication. The material supplied by Koi Peptides is for laboratory and research use only.
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