A synthetic 29-amino-acid analog of growth-hormone-releasing hormone (GHRH 1-29), supplied as sterile lyophilized powder for in-vitro endocrinology research.
$59.95–$99.95Price range: $59.95 through $99.95Out of stock
For laboratory and research use only. Not for human consumption.
This product is not a drug, food or cosmetic. It is sold exclusively to qualified researchers and licensed laboratories.
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US-synthesizedMade & lab-released in the United States
Independent COAThird-party Certificate of Analysis per lot
HPLC + LC-MSPurity by HPLC, identity by mass spectrometry
Same-day dispatchOrders before 2 PM CT ship the same business day
What is Sermorelin?
Sermorelin is a synthetic peptide corresponding to the N-terminal 1-29 residues of growth-hormone-releasing hormone (GHRH), the minimal fragment that retains full GH-releasing activity. It binds the GHRH receptor (GHRH-R) on pituitary somatotrophs and signals through the Gs / adenylyl-cyclase / cAMP pathway, the physiological trigger for growth-hormone synthesis and release. Because it acts upstream of the pituitary, it preserves the pulsatile pattern of GH release in physiological models.
Research areas where laboratories buy Sermorelin for in vitro work include GHRH-R binding and cAMP-accumulation assays in receptor-expressing cells, pituitary somatotroph GH-release studies in cell culture and rodent models, GHRH/GHRP secretagogue synergy experiments (for example with Ipamorelin), structure-activity studies of GHRH(1-29) fragments and analogs, and comparative analysis against longer-acting GHRH analogs such as tesamorelin and CJC-1295.
Every lot, independently verified
Independently third-party tested and matched to the lot ID printed on your vial. Values below are from the latest released lot.
Every lot is released against Koi's full QC panel — HPLC purity, LC-MS identity, net content, heavy metals, sterility, and endotoxin — by an independent third-party laboratory (Freedom Diagnostics Testing). Values shown are from the latest released lot and vary batch to batch; the lot-specific certificate is published in our public COA library and matched to the lot ID printed on the vial.
Browse full COA library →
Compound information
Chemical & structural reference data — specifications, molecular profile and handling.
Storage · powder−20 °C, desiccated, dark (−80 °C long-term)
In solution2–8 °C; aliquot & freeze, avoid freeze-thaw
Sermorelin Mechanism of Action
Binds the growth-hormone-releasing-hormone receptor (GHRH-R) on pituitary somatotrophs, the physiological trigger for GH synthesis and release.
Signals through Gs / adenylyl-cyclase / cAMP, raising intracellular cAMP and stimulating GH gene transcription and secretion.
Corresponds to the N-terminal 1-29 residues of native GHRH, the minimal fragment that retains full GH-releasing activity.
Acts upstream of, and synergizes with, GHS-R1a (ghrelin-receptor) agonists such as Ipamorelin in paired secretagogue studies.
Preserves the pulsatile pattern of GH release in physiological models.
Subject to enzymatic cleavage at the N-terminus, a structure-activity consideration addressed by longer-acting GHRH analogs.
Sermorelin Research Applications
GHRH-R binding and cAMP-accumulation assays in receptor-expressing cells.
Pituitary somatotroph GH-release studies in cell culture and rodent models.
GHRH/GHRP secretagogue synergy experiments (e.g. with Ipamorelin).
Structure-activity studies of GHRH(1-29) fragments and analogs.
Pulsatile GH-secretion modeling under defined conditions.
Comparative analysis against longer-acting GHRH analogs (e.g. tesamorelin, CJC-1295).
Why Buy Sermorelin from Koi Peptides?
Every batch of Koi Sermorelin is synthesized and lyophilized in the United States, then released against independent third-party laboratory (Freedom Diagnostics Testing) testing.
Each lot is tested by HPLC for purity, LC-MS for identity confirmation, and screened for endotoxin before release.
The lot ID is printed on every vial and ties back to a public COA library, so researchers can verify documentation before they buy and after the vial arrives.
Orders placed before 2 PM CT ship the same business day, and shipping is free on orders over $200.
References
The laboratory and preclinical research behind Sermorelin — cited for scientific context.
Science
Growth hormone-releasing factor from a human pancreatic islet tumor
Guillemin, R., et al. (1982). Growth hormone-releasing factor from a human pancreatic islet tumor. Science, 218(4572), 585–587. doi.org/10.1126/science.6812220
Mayo, K. E., et al. (1995). Growth hormone-releasing hormone and its receptor. Endocrine Reviews, 16(1), 1–30. doi.org/10.1210/edrv-16-1-1
Thorner, M. O., et al. (1983). GRF(1-29)NH2 stimulates growth hormone secretion. Journal of Clinical Endocrinology & Metabolism, 57(2), 367–370.
Regulatory Status
Regulatory status — provided for research context.
Research Use
The sermorelin supplied by Koi Peptides is a research-grade reagent synthesized for laboratory research only. It is not formulated, packaged or labeled as a drug, food or cosmetic, and is not authorized for any human or veterinary use.
Disclaimer
For laboratory and research use only. Not for human consumption. This product is not a drug, food or cosmetic. It is sold exclusively to qualified researchers and licensed laboratories. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Sermorelin is the reference GHRH(1-29) analog for studying GHRH-receptor signaling and pituitary GH release. It is used in GHRH-R binding and cAMP-accumulation assays, somatotroph GH-release models in cell culture and rodents, and GHRH/GHRP secretagogue synergy experiments (for example with Ipamorelin), as well as structure-activity work on GHRH(1-29) fragments.
What purity is Koi's Sermorelin?+
Koi Sermorelin is ≥99% by HPLC (latest released lot 99.40%), with identity confirmed by LC-MS. Every lot is released against third-party testing covering HPLC purity, LC-MS identity, net content, heavy metals, sterility, and endotoxin, and the COA is published against the lot number printed on the vial.
How do I prepare a Sermorelin solution?+
Dissolve in sterile water or a suitable buffer at neutral pH; add diluent down the vial wall and avoid vortexing. Prepare working dilutions before use, and for sterile cell-culture work filter through a 0.22 µm low-protein-binding filter. Store prepared solutions at 2 to 8 °C, or aliquot and freeze at −20 °C or below.
What is the CAS number for Sermorelin?+
The CAS number for Sermorelin is 86168-78-7. It corresponds to GHRH(1-29) amide (GRF 1-29), with a molecular weight of 3357.93 g/mol.
Is Sermorelin for human use?+
No. Sermorelin is for laboratory and research use only and is not for human consumption. It is sold exclusively to qualified researchers and licensed laboratories.
Does Sermorelin come with a Certificate of Analysis?+
Yes. The lot-specific Certificate of Analysis is published in our public COA library and matched to the lot ID printed on the vial. It covers HPLC purity, LC-MS identity, net content, heavy metals, sterility, and endotoxin, so researchers can verify documentation before they buy and after the vial arrives.
How should Sermorelin be stored?+
Store the lyophilized powder at −20 °C, desiccated and protected from light; for long-term storage −80 °C is preferred. Once dissolved, store at 2 to 8 °C or aliquot and freeze. Avoid repeated freeze-thaw cycles.
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